Deletion of the Igκ Light Chain Intronic Enhancer/Matrix Attachment Region Impairs but Does Not Abolish VκJκ Rearrangement
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Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics.
Cardiac titin is the main determinant of sarcomere stiffness during diastolic relaxation. To explore whether titin stiffness affects the kinetics of cardiac myofibrillar contraction and relaxation, we used subcellular myofibrils from the left ventricles of homozygous and heterozygous N2B-knockout mice which express truncated cardiac titins lacking the unique elastic N2B region. Compared with my...
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ژورنال
عنوان ژورنال: Immunity
سال: 1996
ISSN: 1074-7613
DOI: 10.1016/s1074-7613(00)80251-4